Translational Models of Parkinson's Disease and related Movement Disorders
Wael Mohamed
Nov 2024 · Elsevier
Ebook
480
Pages
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About this ebook
Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models. - Highlights induction and validation of different available experimental models of Parkinson's Disease - Provides a comparative prospect of different experimental models of Parkinson's Disease - Discusses the advantages and disadvantages of each model, including associated limitations
About the author
Dr Mohamed is a Psychiatrist Neuroscientist. He earned his medical degree from Menoufia Medical School, Egypt and his research doctorate degree from the Penn State University, USA. After finishing his training in the neurosurgery department, he started his career as a clinical pharmacologist with psychopharmacology as a subspecialty. Currently, he is an assistant professor in IIUM, Malaysia as well as he is a doctorate student in cognitive psychology, IIUM, Malaysia. His translational brain research targets the investigation and development of novel treatment for AD and PD using rat, mice, and Zebra Fish animal models.
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