This edition contains articles presented and selected from 5th International Conference on Mechanical Engineering (ICOME 2021), virtually held on August 25-26, 2021. The publication considers actual issues in engineering research and design in areas of machinery, biomedical engineering, waste and biomass conversion technologies, as well as quality control and failure analysis in power plant equipment. The publication will be useful to specialists in mechanical engineering, biomedicine, power energy production and environmental engineering.