Structural Genomics, Part B
Andrzej Joachimiak
Π½ΠΎΠ΅. 2009β―Π³. Β· Advances in Protein Chemistry and Structural Biology ΠΠ½ΠΈΠ³Π° 76 Β· Academic Press
Π-ΠΊΠ½ΠΈΠ³Π°
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reportΠΡΠ΅Π½ΠΈΡΠ΅ ΠΈ ΡΠ΅ΡΠ΅Π½Π·ΠΈΠΈΡΠ΅ Π½Π΅ ΡΠ΅ ΠΏΠΎΡΠ²ΡΠ΄Π΅Π½ΠΈ Β ΠΠΎΠ·Π½Π°ΡΡΠ΅ ΠΏΠΎΠ²Π΅ΡΠ΅
ΠΠ° Π΅-ΠΊΠ½ΠΈΠ³Π°Π²Π°
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. - Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy - Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
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ΠΠ° Π΄Π° ΡΠΈΡΠ°ΡΠ΅ Π½Π° ΡΡΠ΅Π΄ΠΈ ΡΠΎ Π΅-ΠΌΠ°ΡΡΠΈΠ»ΠΎ, ΠΊΠ°ΠΊΠΎ ΡΡΠΎ ΡΠ΅ Π΅-ΡΠΈΡΠ°ΡΠΈΡΠ΅ Kobo, ΡΠ΅ ΡΡΠ΅Π±Π° Π΄Π° ΠΏΡΠ΅Π·Π΅ΠΌΠ΅ΡΠ΅ Π΄Π°ΡΠΎΡΠ΅ΠΊΠ° ΠΈ Π΄Π° ΡΠ° ΠΏΡΠ΅ΡΡΠ»ΠΈΡΠ΅ Π½Π° ΡΡΠ΅Π΄ΠΎΡ. Π‘Π»Π΅Π΄Π΅ΡΠ΅ Π³ΠΈ Π΄Π΅ΡΠ°Π»Π½ΠΈΡΠ΅ ΡΠΏΠ°ΡΡΡΠ²Π° Π²ΠΎ Π¦Π΅Π½ΡΠ°ΡΠΎΡ Π·Π° ΠΏΠΎΠΌΠΎΡ Π·Π° ΠΏΡΠ΅ΡΡΠ»Π°ΡΠ΅ Π½Π° Π΄Π°ΡΠΎΡΠ΅ΠΊΠΈΡΠ΅ Π½Π° ΠΏΠΎΠ΄Π΄ΡΠΆΠ°Π½ΠΈ Π΅-ΡΠΈΡΠ°ΡΠΈ.
