The Biology of Cancer: A Comprehensive Guide to the Science of Cancer
Ray Arters
Dedona Publishing
Ebook
29
Pages
family_home
Eligible
info
reportRatings and reviews aren’t verified Learn More
About this ebook
Cancer represents one of the most complex and formidable challenges in modern biology and medicine, characterized by the fundamental breakdown of normal cellular control mechanisms that maintain tissue homeostasis and organismal integrity. At its essence, cancer is a disease of cellular behavior where individual cells escape the regulatory constraints that normally govern their growth, division, and death, leading to uncontrolled proliferation and the potential to invade distant tissues. This transformation from normal to malignant cell behavior involves the accumulation of genetic and epigenetic alterations that progressively disrupt the molecular machinery responsible for maintaining cellular order and cooperation within multicellular organisms.
The hallmarks of cancer, as originally articulated by Douglas Hanahan and Robert Weinberg, provide a conceptual framework for understanding how normal cells become transformed into cancer cells through the acquisition of specific capabilities that enable malignant behavior. These hallmarks include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. More recent updates to this framework have included reprogramming energy metabolism, evading immune destruction, genome instability and mutation, and tumor-promoting inflammation as additional enabling characteristics that support cancer development and progression.
Rate this ebook
Tell us what you think.
Reading information
Smartphones and tablets
Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.
Laptops and computers
You can listen to audiobooks purchased on Google Play using your computer's web browser.
eReaders and other devices
To read on e-ink devices like Kobo eReaders, you'll need to download a file and transfer it to your device. Follow the detailed Help Center instructions to transfer the files to supported eReaders.
