Progress in Medicinal Chemistry: Volume 44

┬╖
┬╖ Progress in Medicinal Chemistry рдкреБрд╕реНрддрдХ 44 ┬╖ Elsevier
рдЗ-рдкреБрд╕реНрддрдХ
404
рдкреГрд╖реНрдард╣рд░реВ
рдпреЛрдЧреНрдп
рд░реЗрдЯрд┐рдЩ рд░ рд░рд┐рднреНрдпреВрд╣рд░реВрдХреЛ рдкреБрд╖реНрдЯрд┐ рдЧрд░рд┐рдПрдХреЛ рд╣реБрдБрджреИрди ┬ардердк рдЬрд╛рдиреНрдиреБрд╣реЛрд╕реН

рдпреЛ рдЗ-рдкреБрд╕реНрддрдХрдХрд╛ рдмрд╛рд░реЗрдорд╛

The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

рд▓реЗрдЦрдХрдХреЛ рдмрд╛рд░реЗрдорд╛

Dr Geoff Lawton has extensive experience in new medicine discovery across many therapeutic areas in both large and small companies and is a co-inventor of a marketed drug (Cilazapril). He is a former Director of Chemistry at Roche UK, and Vice-president Chemistry and Preclinical Sciences within Roche Bioscience, Palo Alto, USA. He was for five years the research member of a global therapy area strategy planning team for inflammatory diseases, aligning research with the clinical development and marketing parts of the business.From 2003 to 2007 he was founding Research Director with Lectus Therapeutics building from start-up a drug discovery organisation; generating the team, facilities and project portfolio targeting the next generation of ion channel modulating medicines. Since 2001 Geoff has provided scientific and strategic evaluation and advice on drug discovery as an independent consultant for a number small and medium sized biotech companies, CROs, VCs, academic groups and medical research charities. Geoff serves on the Board of Antabio, a French biotech company developing tomorrowтАЩs antibacterial drugs.He is a founder of INMedD, a new medicines discovery social enterprise.

рдпреЛ рдЗ-рдкреБрд╕реНрддрдХрдХреЛ рдореВрд▓реНрдпрд╛рдЩреНрдХрди рдЧрд░реНрдиреБрд╣реЛрд╕реН

рд╣рд╛рдореАрд▓рд╛рдИ рдЖрдлреНрдиреЛ рдзрд╛рд░рдгрд╛ рдмрддрд╛рдЙрдиреБрд╣реЛрд╕реНред

рдЬрд╛рдирдХрд╛рд░реА рдкрдвреНрджреИ

рд╕реНрдорд╛рд░реНрдЯрдлреЛрди рддрдерд╛ рдЯреНрдпрд╛рдмрд▓реЗрдЯрд╣рд░реВ
Android рд░ iPad/iPhone рдХрд╛ рд▓рд╛рдЧрд┐┬аGoogle Play рдХрд┐рддрд╛рдм рдПрдк рдХреЛ рдЗрдиреНрд╕реНрдЯрд▓ рдЧрд░реНрдиреБрд╣реЛрд╕реНред рдпреЛ рддрдкрд╛рдИрдВрдХреЛ рдЦрд╛рддрд╛рд╕реЕрдВрдЧ рд╕реНрд╡рддрдГ рд╕рд┐рдВрдХ рд╣реБрдиреНрдЫ рд░ рддрдкрд╛рдИрдВ рдЕрдирд▓рд╛рдЗрди рд╡рд╛ рдЕрдлрд▓рд╛рдЗрди рдЬрд╣рд╛рдБ рднрдП рдкрдирд┐┬ардЕрдзреНрдпрдпрди рдЧрд░реНрди рджрд┐рдиреНрдЫред
рд▓реНрдпрд╛рдкрдЯрдк рддрдерд╛ рдХрдореНрдкреНрдпреБрдЯрд░рд╣рд░реВ
рддрдкрд╛рдИрдВ Google Play рдорд╛ рдЦрд░рд┐рдж рдЧрд░рд┐рдПрдХреЛ рдЕрдбрд┐рдпреЛрдмреБрдХ рдЖрдлреНрдиреЛ рдХрдореНрдкреНрдпреБрдЯрд░рдХреЛ рд╡реЗрдм рдмреНрд░рд╛рдЙрдЬрд░ рдкреНрд░рдпреЛрдЧ рдЧрд░реЗрд░ рд╕реБрдиреНрди рд╕рдХреНрдиреБрд╣реБрдиреНрдЫред
eReaders рд░ рдЕрдиреНрдп рдЙрдкрдХрд░рдгрд╣рд░реВ
Kobo eReaders рдЬрд╕реНрддрд╛ e-ink рдбрд┐рднрд╛рдЗрд╕рд╣рд░реВрдорд╛ рдлрд╛рдЗрд▓ рдкрдвреНрди рддрдкрд╛рдИрдВрд▓реЗ рдлрд╛рдЗрд▓ рдбрд╛рдЙрдирд▓реЛрдб рдЧрд░реЗрд░ рдЙрдХреНрдд рдлрд╛рдЗрд▓ рдЖрдлреНрдиреЛ рдбрд┐рднрд╛рдЗрд╕рдорд╛ рдЯреНрд░рд╛рдиреНрд╕реНрдлрд░ рдЧрд░реНрдиреБ рдкрд░реНрдиреЗ рд╣реБрдиреНрдЫред рддреА рдлрд╛рдЗрд▓рд╣рд░реВ рдкрдвреНрди рдорд┐рд▓реНрдиреЗ рдЗрдмреБрдХ рд░рд┐рдбрд░рд╣рд░реВрдорд╛ рддреА рдлрд╛рдЗрд▓рд╣рд░реВ рдЯреНрд░рд╛рдиреНрд╕реНрдлрд░ рдЧрд░реНрдиреЗрд╕рдореНрдмрдиреНрдзреА рд╡рд┐рд╕реНрддреГрдд рдирд┐рд░реНрджреЗрд╢рдирд╣рд░реВ рдкреНрд░рд╛рдкреНрдд рдЧрд░реНрди рдорджреНрджрдд рдХреЗрдиреНрджреНрд░ рдорд╛ рдЬрд╛рдиреБрд╣реЛрд╕реНред

рдпреЛ рд╢реГрдЩреНрдЦрд▓рд╛рдХрд╛ рдмрд╛рдБрдХреА рдкреБрд╕реНрддрдХ рдкрдвреНрдиреБрд╣реЛрд╕реН

рдЙрд╕реНрддреИ рдЗ-рдкреБрд╕реНрддрдХрд╣рд░реВ