Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics

M. Flint Beal · Anthony E. Lang · Albert C. Ludolph

qer 2005 · Cambridge University Press

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Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

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Flint Beal is Anne Parrish Titzell Professor and Chairman of the Department of Neurology and Neuroscience at the Weill Medical College of Cornell University, and Director of Neurology at the New York Presbyterian Cornell Campus. An internationally recognized authority on neurodegenerative disorders, his research has focused on the mechanism of neuronal degeneration in Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis.

Anthony Lang is Professor in the Department of Medicine, Division of Neurology, University of Toronto. A founding member of the Parkinson Study Group and the Movement Disorders Society, his research has included clinical trials of poorly recognized neurological disorders, clinical trials of new therapeutic modalities, and studies in molecular biology, neurophysiology, neuropsychology and imaging.

Albert Ludolph is Professor of Neurology, Chair of Neurology, and Chairman of the Neuroscience Center of the University of Ulm, Germany. A neurologist and psychiatrist, his major interest is in toxicological models of vulnerability and genetic models for the pathogenesis of neurodegenerative diseases.

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