MicroRNA: From Bench to Bedside

Junjie Xiao

korr 2022 · Academic Press

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654

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MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation. - Covers the topic of microRNA in detail, from foundational knowledge to clinical application - Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases - Discusses future directions and challenges in the field - Includes chapters on methodology and bioinformatics for microRNA research

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Dr. Junjie Xiao is Professor and Vice Dean of School of Life Science, and also the Vice Dean of School of Medicine, at Shanghai University, People's Republic of China. Dr. Xiao is the Associate Editor of the Journal of Cardiovascular Translational Research, BMC Sports and Science, Medicine and Rehabilitation, and Frontiers in Cardiovascular Medicine. He is also the member of the editorial board of BMC Medicine, Journal of Molecular and Cellular Cardiology, Journal of Sport and Health Science, Cell Transplantation, Current Stem Cell Research & Therapy, Journal of Thoracic Disease, and Biomedical and Environmental Sciences. He is the author or co-author of 140 scientific articles in various journals and his major research interest is studying the comprehensive intervention and risk warning of heart failure, especially using exercise as a platform to identify novel targets, including non-coding RNAs and functional proteins, for enhancing cardiac regeneration and combating heart failure.

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