Lead-Seeking Approaches

Matthew M. Hayward

ମାର୍ଚ୍ଚ 2010 · Topics in Medicinal Chemistry 5 ବହି · Springer Science & Business Media

ଇବୁକ୍

217

ପୃଷ୍ଠାଗୁଡ଼ିକ

ରେଟିଂ ଓ ସମୀକ୍ଷାଗୁଡ଼ିକୁ ଯାଞ୍ଚ କରାଯାଇନାହିଁ ଅଧିକ ଜାଣନ୍ତୁ

ଏହି ଇବୁକ୍ ବିଷୟରେ

High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].

ଏହି ଇବୁକ୍‍କୁ ମୂଲ୍ୟାଙ୍କନ କରନ୍ତୁ

ଆପଣ କଣ ଭାବୁଛନ୍ତି ତାହା ଆମକୁ ଜଣାନ୍ତୁ।

ପଢ଼ିବା ପାଇଁ ତଥ୍ୟ

ସ୍ମାର୍ଟଫୋନ ଓ ଟାବଲେଟ

Google Play Books ଆପ୍କୁ, Android ଓ iPad/iPhone ପାଇଁ ଇନଷ୍ଟଲ୍ କରନ୍ତୁ। ଏହା ସ୍ଵଚାଳିତ ଭାବେ ଆପଣଙ୍କ ଆକାଉଣ୍ଟରେ ସିଙ୍କ ହୋ‍ଇଯିବ ଏବଂ ଆପଣ ଯେଉଁଠି ଥାଆନ୍ତୁ ନା କାହିଁକି ଆନଲାଇନ୍ କିମ୍ବା ଅଫଲାଇନ୍‍ରେ ପଢ଼ିବା ପାଇଁ ଅନୁମତି ଦେବ।

ଲାପଟପ ଓ କମ୍ପ୍ୟୁଟର

ନିଜର କମ୍ପ୍ୟୁଟର୍‍ରେ ଥିବା ୱେବ୍ ବ୍ରାଉଜର୍‍କୁ ବ୍ୟବହାର କରି Google Playରୁ କିଣିଥିବା ଅଡିଓବୁକ୍‍କୁ ଆପଣ ଶୁଣିପାରିବେ।

ଇ-ରିଡର୍ ଓ ଅନ୍ୟ ଡିଭାଇସ୍‍ଗୁଡ଼ିକ

Kobo eReaders ପରି e-ink ଡିଭାଇସଗୁଡ଼ିକରେ ପଢ଼ିବା ପାଇଁ, ଆପଣଙ୍କୁ ଏକ ଫାଇଲ ଡାଉନଲୋଡ କରି ଏହାକୁ ଆପଣଙ୍କ ଡିଭାଇସକୁ ଟ୍ରାନ୍ସଫର କରିବାକୁ ହେବ। ସମର୍ଥିତ eReadersକୁ ଫାଇଲଗୁଡ଼ିକ ଟ୍ରାନ୍ସଫର କରିବା ପାଇଁ ସହାୟତା କେନ୍ଦ୍ରରେ ଥିବା ସବିଶେଷ ନିର୍ଦ୍ଦେଶାବଳୀକୁ ଅନୁସରଣ କରନ୍ତୁ।

ବେଆଇନ ବିଷୟବସ୍ତୁର ରିପୋର୍ଟ କର