The 29 full papers included in this book were carefully reviewed and selected from 91 submissions. They cover a wide range of CBR topics of interest both to practitioners and researchers, including: improvements to the CBR methodology itself: case representation, similarity, retrieval, adaptation, etc.; synergies with other Artificial Intelligence topics, such as Explainable AI and Large Language Models; and finally a whole catalog of applications to different domains such as health-care, education, and legislation.