Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development
Jae Lee · R. Scott Obach · Michael B. Fisher
Sep 2003 · CRC Press
Ebook
608
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About this ebook
Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.
About the author
Jae Lee, R. Scott Obach, Michael B. Fisher
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