"Hemophilia B: Advances in Pathophysiology, Treatment Strategies, and Emerging Therapies" is a comprehensive treatise exploring the intricate aspects of this rare genetic bleeding disorder. Delving into the pathophysiological mechanisms underlying Factor IX deficiency, it navigates through cutting-edge treatment strategies including gene therapy, extended half-life Factor IX products, and novel therapies. The treatise elucidates clinical manifestations, severity grading, and complications such as joint and CNS bleeds, while also covering laboratory testing, genetic diagnostics, and prenatal screening. With a focus on personalized medicine and gene editing technologies, it examines ethical considerations, global health challenges, and initiatives to enhance access to care. This authoritative work integrates medical insights, research advancements, and future perspectives, offering a vital resource for healthcare professionals, researchers, and stakeholders invested in advancing Hemophilia B management worldwide.