G-Protein-Coupled Receptor Dimers

Katharine Herrick-Davis · Graeme Milligan · Giuseppe Di Giovanni

2017년 8월 · Springer

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eBook 정보

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

저자 정보

Katharine Herrick-Davis is Professor of Neuroscience and Experimental Therapeutics at Albany Medical College, Albany, USA. Her research has focused on investigating receptor dimerization and how it affects receptor function using the 5-HT2C receptor as a model system.
Graeme Milligan is Professor of Molecular Pharmacology, University of Glasgow, U.K. he is the Dean of Research, College of Medical, Veterinary and Life Sciences, University of Glasgow. His main research group centres on the function, structure and regulation of GPCRs and their interacting proteins.
Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and Treasurer of the Mediterranean Neuroscience Society. His research has focused on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.