Functional Proteomics

Luke Erber is a scientist studying epigenetics and post-translational modifications. He received his B.Sc. in Biology and Chemistry from Concordia University Chicago and his Ph.D. in Biochemistry with Dr. Yue Chen from the University of Minnesota in 2019. He is currently an NIH-funded Training Research Educators in Minnesota Postdoctoral Fellow with Dr. Natalia Tretyakova and Dr. William Pomerantz at the University of Minnesota. He is interested in applying quantitative mass spectrometry to study DNA damage pathways and epigenetic regulators of histone modifications.

Yue Chen is currently an Associate Professor in the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, Twin Cities. He earned his B.Sc. in Chemistry from Peking University in China and his Ph.D. in Biochemistry with Dr. Yingming Zhao at the University of Texas, Arlington, in 2009. After a postdoctoral training at the University of Chicago in the field of proteomic analysis of lysine short-chain acylations, he began his faculty position at the University of Minnesota in 2013. He is interested in applying functional proteomic strategies to discover and biochemically characterize metabolic-sensing posttranslational modification pathways in protein homeostasis and epigenetic regulation. His work has revealed new oxygen-sensing proline hydroxylation pathways and hypoxia-mediated DNA damage responses. He has developed chemical proteomics strategies for system-wide, site-specific quantification of lysine acetylation and ubiquitination stoichiometries. He has authored more than 70 peer-reviewed publications and received an NIH MIRA Award as well as an NSF CAREER Award.