The book takes a structured approach, starting with the fundamentals of conditioning, such as strength, power, endurance, and agility. It then examines specific training methodologies used by elite fighters across various disciplines. Each chapter dissects a particular method, analyzing its benefits, risks, and scientific validity. By contrasting real-world training with exaggerated manga sequences, Extreme Conditioning underscores the importance of evidence-based training, offering practical guidelines for incorporating these principles into personalized fitness routines, and emphasizes the importance of individualized programming and professional guidance.