Professor Dhavendra Kumar, MD, FRCP, FACM, Consultant in Clinical Genetics, Institute of Medical Genetics (Cardiff University), Genomic Policy Unit (University of Glamorgan), University Hospital of Wales, Cardiff University, Cardiff, UK Professor Charis Eng, MD, PhD, FACP, ACS/Hardis Professor and Chairwoman of the Genomic Medicine Institute and Director of the Center for Personalized Genetic Healthcare, The Cleveland Clinic, Ohio, USA; Professor and Vice Chair of the Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA