Cytoplasmic fate of messenger RNA

· Progress in Molecular and Subcellular Biology Книга 18 · Springer Science & Business Media
Π•-ΠΊΠ½ΠΈΠ³Π°
224
Π‘Ρ‚Ρ€Π°Π½ΠΈΡ†ΠΈ
ΠžΡ†Π΅Π½ΠΈΡ‚Π΅ ΠΈ Ρ€Π΅Ρ†Π΅Π½Π·ΠΈΠΈΡ‚Π΅ Π½Π΅ сС ΠΏΠΎΡ‚Π²Ρ€Π΄Π΅Π½ΠΈ Β Π”ΠΎΠ·Π½Π°Ρ˜Ρ‚Π΅ повСќС

Π—Π° Π΅-ΠΊΠ½ΠΈΠ³Π°Π²Π°

Among all cellular RNA species of the three main types, ribosomal RNA, transfer RNA or messenger RNA, be they from prokaryotic or eukaryotic organisms, the prokaryotic mRNA is unique in that it has no precursor and is synthesized in the same mature form as it is translated into proteins. In fact, ribosomes join the nascent mRNA chain and engage in protein synthesis long before its transcription is complete. Provisions are even made for slowing down the ribo somes at some sites to prevent them from catching up with the RNA-polymerase. Of course, such a situation is only possible in the prokaryotic world where there is no such thing as a nuclear mem brane physically secluding the transcription process from the cy toplasm where translation is restricted. Quite in the opposite extreme, the eukaryotic pre-messenger RNA has to suffer many and sometimes drastic steps of maturation (capping, polyadenylation, splicing, edition) before the decision is made to export it to the cytoplasm. That is where it enters the scope of this book. Once in the cytoplasm, many options are still open to it: its entrance into polysomes may be delayed (as it is in unfertilized eggs) or merely prohibited (ferritin mRNA in iron-starved cells), directed to specific locations within the cytoplasm or be more or less rapidly degraded. During gametogenesis and early development, translational control is probably the most significant level of gene expression.

ΠžΡ†Π΅Π½Π΅Ρ‚Π΅ ја Π΅-ΠΊΠ½ΠΈΠ³Π°Π²Π°

ΠšΠ°ΠΆΠ΅Ρ‚Π΅ Π½ΠΈ ΡˆΡ‚ΠΎ мислитС.

Π˜Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ Π·Π° Ρ‡ΠΈΡ‚Π°ΡšΠ΅

ΠŸΠ°ΠΌΠ΅Ρ‚Π½ΠΈ Ρ‚Π΅Π»Π΅Ρ„ΠΎΠ½ΠΈ ΠΈ Ρ‚Π°Π±Π»Π΅Ρ‚ΠΈ
Π˜Π½ΡΡ‚Π°Π»ΠΈΡ€Π°Ρ˜Ρ‚Π΅ ја Π°ΠΏΠ»ΠΈΠΊΠ°Ρ†ΠΈΡ˜Π°Ρ‚Π° Google Play Books Π·Π° Android ΠΈ iPad/iPhone. Автоматски сС синхронизира со смСтката ΠΈ Π²ΠΈ ΠΎΠ²ΠΎΠ·ΠΌΠΎΠΆΡƒΠ²Π° Π΄Π° Ρ‡ΠΈΡ‚Π°Ρ‚Π΅ онлајн ΠΈΠ»ΠΈ ΠΎΡ„Π»Π°Ρ˜Π½ ΠΊΠ°Π΄Π΅ ΠΈ Π΄Π° стС.
Π›Π°ΠΏΡ‚ΠΎΠΏΠΈ ΠΈ ΠΊΠΎΠΌΠΏΡ˜ΡƒΡ‚Π΅Ρ€ΠΈ
МоТС Π΄Π° ΡΠ»ΡƒΡˆΠ°Ρ‚Π΅ Π°ΡƒΠ΄ΠΈΠΎΠΊΠ½ΠΈΠ³ΠΈ ΠΊΡƒΠΏΠ΅Π½ΠΈ ΠΎΠ΄ Google Play со ΠΊΠΎΡ€ΠΈΡΡ‚Π΅ΡšΠ΅ Π½Π° Π²Π΅Π±-прСлистувачот Π½Π° ΠΊΠΎΠΌΠΏΡ˜ΡƒΡ‚Π΅Ρ€ΠΎΡ‚.
Π•-Ρ‡ΠΈΡ‚Π°Ρ‡ΠΈ ΠΈ Π΄Ρ€ΡƒΠ³ΠΈ ΡƒΡ€Π΅Π΄ΠΈ
Π—Π° Π΄Π° Ρ‡ΠΈΡ‚Π°Ρ‚Π΅ Π½Π° ΡƒΡ€Π΅Π΄ΠΈ со Π΅-мастило, ΠΊΠ°ΠΊΠΎ ΡˆΡ‚ΠΎ сС Π΅-Ρ‡ΠΈΡ‚Π°Ρ‡ΠΈΡ‚Π΅ Kobo, ќС Ρ‚Ρ€Π΅Π±Π° Π΄Π° ΠΏΡ€Π΅Π·Π΅ΠΌΠ΅Ρ‚Π΅ Π΄Π°Ρ‚ΠΎΡ‚Π΅ΠΊΠ° ΠΈ Π΄Π° ја ΠΏΡ€Π΅Ρ„Ρ€Π»ΠΈΡ‚Π΅ Π½Π° ΡƒΡ€Π΅Π΄ΠΎΡ‚. Π‘Π»Π΅Π΄Π΅Ρ‚Π΅ Π³ΠΈ Π΄Π΅Ρ‚Π°Π»Π½ΠΈΡ‚Π΅ упатства Π²ΠΎ Π¦Π΅Π½Ρ‚Π°Ρ€ΠΎΡ‚ Π·Π° помош Π·Π° ΠΏΡ€Π΅Ρ„Ρ€Π»Π°ΡšΠ΅ Π½Π° Π΄Π°Ρ‚ΠΎΡ‚Π΅ΠΊΠΈΡ‚Π΅ Π½Π° ΠΏΠΎΠ΄Π΄Ρ€ΠΆΠ°Π½ΠΈ Π΅-Ρ‡ΠΈΡ‚Π°Ρ‡ΠΈ.