Conversations on Cardiac Physiology: Heart Fallacies
Mark Noble
Des 2023 · Cambridge Scholars Publishing
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This book addresses and corrects widespread misconceptions regarding heart physiology. Such misconceptions include: the voltage in cells is attributed to potassium ion concentration differences between the extracellular and intracellular compartments, which are the same in all organs of the body, whereas the voltage in cells of these same organs vary widely.
This book argues that depolarisation and repolarisation can be explained by electron outflow and mitochondrial production, respectively; and that the trigger for internal calcium ion release is calcium ions bound to the inner leaflet of the cell membrane. In the book, Starling’s Law is contrasted with contractility increase, and it is posited that hypertension is not caused by salty diet, coronary artery disease risk is not correlated with total cholesterol (rather, only with some specific cholesterols), and that drug administration should be titrated.
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Mark Noble, Honorary Professor of Cardiovascular Medicine at Aberdeen University, was educated at the University of London, where he gained his three doctorates, and at Midhurst Medical Research Institute. He is a fellow of the Royal College of Medicine of London, the European Society of Cardiology, the Royal Society of Medicine and the Association of Physicians. He has also held the prestigious visiting professorships of Boerhaave Professor of Medicine at the University of Leiden, and Spinola Professor of Medicine at the University of Amsterdam. His last position in the University of London was that of Professor of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London. Noble studies the cardiovascular and respiratory systems, and has published 7 books, 24 book chapters and 271 papers.
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