Carbohydrate Synthesis
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Chapter 1 introduces the basics of carbohydrate structure. Chapter 2 introduces the various roles carbohydrates play in biology. Chapter 3 discusses the glycosylation reaction used to assemble oligosaccharides along with a survey of commonly used glycosyl donors. Chapter 4 discusses commonly used protecting groups. Chapter 5 covers advances in automating the carbohydrate synthesis. Chapter 6 introduces the role of enzymes in the synthesis of homogeneous carbohydrates and glycoproteins.
The authors hope this primer will introduce the uninitiated to the challenges and beauty of carbohydrate synthesis and inspire them to bring a new perspective and new advances to the field. Only by doing so will we, as a community of synthetic chemists, be able to tame one of the last and arguably most complex areas of chemical space to create new advances in human health.
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Clay S. Bennett received his B.A. in Chemistry from Connecticut College in 1999. He then obtained his Ph.D. under the direction of Amos B. Smith, III, at the University of Pennsylvania in 2005. Following postdoctoral studies with Chi-Huey Wong at the Scripps Research Institute, he started his independent career at Tufts University in 2008, where he is currently Professor of Chemistry. His current research focuses on the development of new glycosylation methodologies, their application to the synthesis of antimicrobial oligosaccharides, and the development of automated process for oligosaccharide synthesis.
Tu-Anh V. Nguyen earned her B.S. in Biochemistry from Tufts University in 2022, where she conducted research on the automated processes for deoxy and azido sugar synthesis in the Bennett Lab. Her research interests lie in the intersection of organic synthesis and chemical biology. She is now pursuing her graduate studies in the Department of Chemistry at New York University.
