Spherical Nucleic Acid: Harnessing Nanostructure Design for Targeted Molecular Interactions

Discover the groundbreaking world of Spherical Nucleic Acid (SNA) in this comprehensive work, where DNA origami techniques intersect with cuttingedge nanotechnology. This book is a mustread for professionals, students, and enthusiasts seeking to explore the latest advancements in the molecular sciences. Through the lens of SNA, this book covers essential concepts and applications in nanoparticle assembly, intracellular delivery, and nucleic acid technologies.

Chapters Brief Overview:

1: Spherical nucleic acid: An introduction to SNA, exploring its unique properties and its significance in nanotechnology.

2: Selfassembly of nanoparticles: Understanding how nanoparticles can autonomously organize, forming complex structures.

3: Polyvalent DNA gold nanoparticles: Exploring the interactions between DNA and gold nanoparticles, with applications in diagnostics and therapeutics.

4: Intracellular delivery: Examining methods for delivering nanoparticles and nucleic acids into living cells for medical purposes.

5: Nanoparticle: Overview of different nanoparticle types, their synthesis, and their role in SNA technology.

6: Rolling circle replication: An indepth look at the process of rolling circle replication and its applications in creating DNAbased structures.

7: Chad Mirkin: A profile of Chad Mirkin’s contributions to the field of spherical nucleic acids and DNA nanotechnology.

8: Nucleic acid secondary structure: Delving into the importance of secondary structures in nucleic acids and their impact on SNA formation.

9: Niles Pierce: Exploring Niles Pierce’s contributions to the development of DNA nanotechnology and its impact on SNA research.

10: Colloidal gold: A discussion on the use of colloidal gold in SNA applications, particularly in diagnostics and drug delivery.

11: DNA nanotechnology: Understanding the principles of DNA nanotechnology, with a focus on its applications in creating molecular devices.

12: Lipidbased nanoparticle: Examining the role of lipidbased nanoparticles in drug delivery and gene therapy.

13: Platinum nanoparticle: Investigating the use of platinum nanoparticles in SNA technology, particularly in cancer treatment.

14: Triplestranded DNA: Exploring the creation and application of triplestranded DNA in the context of spherical nucleic acids.

15: Guangzhao Mao: A tribute to Guangzhao Mao’s research and innovations in DNA nanotechnology and its applications.

16: Peptide nucleic acid: Understanding peptide nucleic acid and its role in enhancing the functionality of SNAbased systems.

17: Deoxyribozyme: A focus on deoxyribozymes, their catalytic functions, and how they integrate with SNA technology.

18: Selfassembly: Exploring selfassembly processes in nanotechnology and their role in creating complex DNAbased structures.

19: Polyvalency (chemistry): A look at polyvalency in chemistry, and its significance in the development of multifunctional SNA systems.

20: Magnetic nanoparticles: Investigating the role of magnetic nanoparticles in drug delivery and molecular imaging using SNA.

21: Core–shell semiconductor nanocrystal: An overview of coreshell semiconductor nanocrystals and their applications in DNA nanotechnology.

This book provides both theoretical insights and practical knowledge, making it indispensable for anyone looking to advance their understanding of DNA origami and SNA applications. Whether you're a student exploring molecular biology or a professional developing cuttingedge therapies, the knowledge within these pages is invaluable.